martes, 1 de marzo de 2016

Primera declaracion de Zika autoctono en Brasil e inicio de la epidemia, releyendo el artículo


Leyendo el artículo First report of autochthonous transmission of Zika virus in Brazil buscando el inicio de la epidemia de infecciones por virus zika veo que dicen:

In the early 2015, records of patients presenting a "dengue-like syndrome" appeared in the public health service in the city of Natal (05°47’42"S 35°12’32"O), state of Rio Grande do Norte, Brazil.

y continuan diciendo

By March 2015, the Molecular Virology Laboratory of Carlos Chagas Institute, Oswaldo Cruz Institute, state of Paraná, Brazil, received 21 acute-phase serum specimens from those patients exhibiting the "dengue-like syndrome".

Es decir, en marzo ya tenían 21 sueros correspondientes a pacientes con "dengue-like syndrome"

Amplicons of 364 bp encompassing the envelope protein coding region were obtained for eight out of 21 samples (Fig. 1). Two of the resultant amplicons were purified with High Pure PCR Purification kit (Roche) and sequenced in an ABI 3500 Genetic Analyzer (Applied Biosystems). Sequences were assembled using the Assembler tool (hpa-bioinformatics.org.uk/cgi-bin/assembly_tool/seq_assemble.cgi?no=2) (GenBank accessions KR815989 and KR815990) and their identity were confirmed by Basic Local Alignment Search Tool (BLAST) and compared to other ZIKV sequences. Results demonstrated a high identity with sequences from the ZIKV Asian lineage. Despite the similarity of the clinical findings, the remaining samples resulted negative in RT-PCR, probably due to the short (and low) viraemia period (between the 3rd and 5th day after the onset of clinical symptoms).

Por todo ello, más parece que pudiera considerarse febrero como inicio de la epidemia más que mayo como venimos leyendo.

No hay comentarios:

Publicar un comentario